Advanced Course in Pharmaceutics - Pharmaceutics 201

Pharmaceutics is a multidisciplinary science. It is the study of physical, chemical and biological properties of drugs and dosage forms. It focuses on the delivery, disposition and effectiveness of drugs in the human body. The paradox of modern pharmaceutics is that it includes other areas of pharmaceutical sciences in it. The objective of this course is to provide students the foundation to apply scientific principles to solve problems encountered in the design, development and evaluation of conventional as well as newer dosage forms or drug delivery systems.

Module 1: Physiochemical properties of drugs
Chapter 1 pKa and degree of ionization
Chapter 2 Lipid/water partition coefficient
Chapter 3 Other physiochemical properties of drugs affecting bioavailability
Chapter 4 Distribution of drugs
Chapter 5 Metabolism of drugs
Chapter 6 Urinary excretion
Chapter 7 Rate and rate constant
Chapter 8 Compartment modeling
Chapter 9 Clearance
Chapter 10 Drug dosage regimen

Module 2: Drug transport
Chapter 1 Mechanism of drug absorption
Chapter 2 Barriers to drug transport
Chapter 3 Drug transporter molecules
Chapter 4 Role of dosage forms in drug absorption
Chapter 5 Bioavailability
Chapter 6 Bioequivalence
Chapter 7 Absorption kinetics
Chapter 8 Biopharmaceutic classification system

Module 3: Drug development processes and dosage forms
Chapter 1 Introduction to drug development
Chapter 2 Stereospecific metabolism
Chapter 3 In vitro models used in absorption studies
Chapter 4 Advances in dosage forms
Chapter 5 Chronotherapeutics
Chapter 6 Equillibria of pharmaceutical importance

Module 4: Pharmacological and toxicological properties of new molecules
Chapter 1 Molecular modeling, principles, methods and application of QSAR
Chapter 2 Drug analysis and assay validation
Chapter 3 Clinical Research
Chapter 4 Immunoanalytical chemistry
Chapter 5 Radiation spectroscopy
Chapter 6 Pharmacogenetics
Chapter 7 First dose size and forensic pharmacokinetics